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Karolinska Institutet
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2 days ago
Postdoctoral Researcher in Human Stem Cell Biology and Adipose Tissue Development Karolinska Institutet in Sweden
Degree Level
Postdoc
Field of study
Biology
Funding
Available
Deadline
Nov 18, 2026
Country
Sweden
University
Karolinska Institutet
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About this position
The postdoctoral project is based in the Rydén and Mejhert laboratory at Karolinska Institutet, a multidisciplinary group of around 15–20 researchers working across preclinical and clinical settings. The team studies how altered human white adipocyte function contributes to cardiometabolic disease, with research connected to type 2 diabetes, dyslipidemia, and atherosclerosis.
The successful candidate will investigate how distinct human adipose stem and progenitor cell populations control cell fate and organize developing adipose tissue. The project combines human cell models with transplantation, lineage tracing, single-cell and spatial approaches to define lineage relationships among progenitor populations, their contribution to tissue formation, and the mechanisms that allow transplanted cells to establish adipose tissue in vivo.
Experimental work will bring together cell culture, fluorescence-activated cell sorting, genetic manipulation, in vivo transplantation, tissue imaging, single-cell RNA sequencing, and spatial transcriptomic profiling. A dedicated bioinformatician will handle computational analyses, while the postdoctoral researcher will lead experimental design, method development, data generation, and interpretation. Validation of spatial transcriptomic findings through immunostaining and microscopy is an integral part of the project.
The work is embedded in a strong translational environment spanning Biomedicum and Karolinska University Hospital, Huddinge, with close links to metabolic disease research and opportunities to build an independent research profile.
Funding details
Available
What's required
A PhD or a foreign degree deemed equivalent to a Swedish PhD is required and must be completed by the time of the employment decision. Completion within the last three years is considered an advantage, although earlier completion may be accepted for special reasons. The ideal candidate should have a strong background in experimental cell biology, stem cell biology, developmental biology, or a related field, with hands-on mammalian cell culture and molecular techniques. Experience with flow cytometry and cell sorting, mouse models, cell transplantation or tissue regeneration, CRISPR-based genetic manipulation, stable cell labeling or lineage tracing, immunostaining, fluorescence microscopy, and quantitative image analysis is highly valued. Applicants must be able to independently design, perform, troubleshoot, and manage experiments, work collaboratively, and demonstrate intellectual curiosity, scientific rigor, and effective English communication; proficiency in written and spoken English is required.
How to apply
Prepare the required documents in English or Swedish: a complete CV/resumé, a complete list of publications, and a summary of current work of no more than one page. Submit the application through the Varbi recruitment system by 2026-11-18.
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