Postdoctoral Researcher in Structural Biology of RNA-Protein Interactions in ALS/FTD Institute of Bioorganic Chemistry Polish Academy of Sciences in Poland

The Institute of Bioorganic Chemistry of the Polish Academy of Sciences invites applications for a postdoctoral researcher (assistant professor) position in the Department of RNA Structural Research. This opportunity is part of the OPUS-28 (LAP) project, conducted in close collaboration with Prof. Boris Rogelj's group at the Jožef Stefan Institute in Ljubljana. The project, led by Associate Professor Agnieszka Kiliszek, focuses on the comprehensive structural and functional analysis of toxic RNA–protein interactions to advance understanding and therapeutic targeting of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

The research aims to elucidate the molecular mechanisms underlying ALS and FTD, particularly the role of 'toxic' RNA molecules and their interactions with proteins that contribute to nerve cell dysfunction and death. Despite extensive studies, the atomic-level details of these RNA–protein complexes remain unknown, representing a significant knowledge gap in the field. The project employs interdisciplinary approaches, including structural biology (cryo-electron microscopy, crystallography), biophysical and biochemical methods, and functional studies in human cells. The anticipated outcomes have high potential for publication in leading scientific journals and for contributing to therapeutic strategies for neurodegenerative diseases.

The position offers a competitive gross salary of approximately 9,450 PLN per month for a period of 48 months, with employment governed by the Polish Labor Code. The successful candidate will design and conduct experimental work, prepare RNA–protein complexes for structural and functional analysis, perform biophysical and biochemical evaluations, and participate in crystallographic or cryo-EM studies. Additional responsibilities include processing and interpreting results, preparing scientific reports and publications, supervising students or PhD candidates, and presenting findings at scientific meetings.

Applicants must hold a PhD in biology, chemistry, or a related discipline, with a strong publication record and experience in biophysical and biochemical evaluation of biomolecules. Proficiency in English and the ability to work both independently and collaboratively are essential. Experience in crystallography or cryoEM is advantageous but not mandatory. Eligibility is subject to NCN requirements regarding the timing and location of the doctoral degree and postdoctoral experience.

To apply, candidates should submit a cover letter, CV, copy of doctoral diploma, and contact details for at least two referees via the eRecruiter portal by 26 January 2026. Selected candidates will be invited for an interview, with final decisions based on research output, relevant experience, and internships. For further information, contact Assoc. Prof. Agnieszka Kiliszek at [email protected].