Bruno Guigas

Associate Professor

Leiden University Medical Center

Netherlands

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Bruno Guigas is an Associate Professor at Leiden University Medical Center in the Netherlands. His research focuses on metabolic adaptation, thrombosis, and immune responses, as evidenced by his recent articles on platelet activation, glyco-tagging of proteins, and the gut-liver axis. He investigates the effects of various stimuli on immune cell behavior and metabolic pathways, contributing to advancements in understanding metabolic diseases and immune functions.

Articles (20)

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2025

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2021

Collaborators (9)

Louise Lantier

Research Associate Professor

Vanderbilt University

UNITED STATES

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Johan Heemskerk

Emeritus Prof. of Cell Biochemistry of Thrombosis and Haemostasis

University of Maastricht

NETHERLANDS

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Benoit Viollet

INSERM

FRANCE

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Martin Giera

Assoc. Prof.

Universitair Medisch Centrum Utrecht

NETHERLANDS

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Anna Zawistowska-Deniziak

Associate Professor

University of Warsaw

POLAND

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owen mcguinness

Professor

Vanderbilt University School of Medicine

UNITED STATES

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Jean‐Marie Bard

FRANCE

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Luc Bertrand

Université catholique de Louvain

BELGIUM

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Caroline Bouzin

Université catholique de Louvain

BELGIUM

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Bruno Guigas

Research Interests

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Articles (20)

Deleting ACC1 in platelets alters phospholipidome and reduces platelet activation and thrombosis in mice

OMIP‐104: A 30‐color spectral flow cytometry panel for comprehensive analysis of immune cell composition and macrophage subsets in mouse metabolic organs

Site-Specific Glyco-Tagging of Native Proteins for the Development of Biologicals.

Timing Matters: Late, but Not Early, Exercise Training Ameliorates MASLD in Part by Modulating the Gut-Liver Axis in Mice.

Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis

AMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism.

S. mansoni -derived omega-1 prevents OVA-specific allergic airway inflammation via hampering of cDC2 migration.

Extracellular vesicles derived from stressed beta cells mediate monocyte activation and contribute to islet inflammation.

DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice.

Metformin: update on mechanisms of action and repurposing potential

Combined GIP receptor and GLP1 receptor agonism attenuates NAFLD in male APOE∗3-Leiden.CETP mice

Early but Not Late Exercise Training in Mice Exacerbates Hepatic Inflammation in Developing Nonalcoholic Fatty Liver Disease

Totum-070, a Polyphenol-Rich Plant Extract, Prevents Hypercholesterolemia in High-Fat Diet-Fed Hamsters by Inhibiting Intestinal Cholesterol Absorption

TOTUM‐63, a plant‐based polyphenol‐rich extract, improves glycaemic control in subjects with prediabetes or early stage newly‐diagnosed type 2 diabetes in a randomized, double‐blind, placebo‐controlled trial

Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis

Effects of a novel polyphenol-rich plant extract on body composition, inflammation, insulin sensitivity, and glucose homeostasis in obese mice

Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation

Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation

The Mannose Receptor: From Endocytic Receptor and Biomarker to Regulator of (Meta)Inflammation.

Effects of Totum-63 on glucose homeostasis and postprandial glycemia: a translational study.

Collaborators (9)

Louise Lantier

Johan Heemskerk

Benoit Viollet

Martin Giera

Anna Zawistowska-Deniziak

owen mcguinness

Jean‐Marie Bard

Luc Bertrand

Caroline Bouzin

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