Johan Heemskerk

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Emeritus Prof. of Cell Biochemistry of Thrombosis and Haemostasis

University of Maastricht

Netherlands

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About

Johan Heemskerk is an Emeritus Professor of Cell Biochemistry of Thrombosis and Haemostasis at Maastricht University in the Netherlands. His research focuses on platelet activation, signaling mechanisms in thrombus formation, and the biochemical aspects of hemostasis. Recent publications include studies on the off-target effects of anticoagulants, modeling calcium signaling in platelets, and exploring platelet proteomics. Heemskerk's work contributes significantly to understanding the molecular basis of thrombotic disorders and their clinical implications.

Recent Grants

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Platelet subsets and priming: functional determinants of haemostasis and vascular protection

Open Date: 2017-01-01

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‘The Poly-Valve’ Polymeric Prosthetic Heart Valve for Life Creative Chemistry for a Sustainable Future

Open Date: 2016-01-01

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GRK 1508: Arterial Remodelling

Open Date: 2008-01-01

Close Date: 2013-12-31

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TAPAS: TArgeting Platelet Adhesion receptors in thrombosiS

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Thrombo-Inflammation in CARDIOvascular disease “TICARDIO”

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2022

Collaborators (24)

Mark Thomas

University of Birmingham

UNITED KINGDOM

Johan Heemskerk

Research Interests

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About

Recent Grants

Articles (20)

Toward standardization and a concerted vision for platelet proteomics research: communication from the SSC of the ISTH.

Primary hemostasis in children with cirrhosis prior to liver transplantation

Extended Modelling of Molecular Calcium Signalling in Platelets by Combined Recurrent Neural Network and Partial Least Squares Analyses

Deleting ACC1 in platelets alters phospholipidome and reduces platelet activation and thrombosis in mice

Platelet activation and signaling in thrombus formation

Procoagulant off-target effect of the direct oral anticoagulant reversal agent andexanet-alfa

Human and mouse platelet transcriptomes and proteomes for phenotyping 3474 genes with hemostatic and platelet traits.

Middle-throughput LC-MS-based Platelet Proteomics with Minute Sample Amounts Using Semiautomated Positive Pressure FASP in 384-Well Format

CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization

Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation

Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan

Reversible Platelet Integrin αIIbβ3 Activation and Thrombus Instability

The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function.

More than reverting tyrosine kinases.

Coagulation Factor XIIIa and Activated Protein C Activate Platelets via GPVI and PAR1

Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling, and thrombus formation.

Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function

GPVI expression is linked to platelet size, age, and reactivity.

Quantitative and qualitative changes in platelet traits of sunitinib-treated patients with renal cell carcinoma in relation to circulating sunitinib levels: a proof-of-concept study.

Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry.

Collaborators (24)

Mark Thomas

Kerstin Jurk

Martine Jandrot-Perrus

Natalie J. Jooss

Martin Giera

Ángel García

Steve P. Watson

Erik Biessen

Johan Duchene

Luis Arturo Moran Lara

Gerry Nicolaes

Alexandre Slater

Alice Assinger

Kanin Wichapong

Tilman Hackeng

Magdolna Nagy

Aaron Iding

Chris Jones

Bruno Guigas

Sofia Ramström

Paola van der Meijden

Jonathan Gibbins

Constance Baaten

Rachel Cavill

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