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Celine Valant

MONASH UNIVERSITY

Australia

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Research Interests

Biochemistry

50%

Pharmacology

100%

G Protein-coupled Receptor

90%

Gpcr

70%

Allosteric Regulation

70%

Neurochemistry

60%

Ligand Design

50%

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Recent Grants

Grant: Open

Modulation of the M4 muscarinic receptor for the treatment of schizophrenia

Open Date: 2023-01-01

Close Date: 2026-12-01

Grant: Open

Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain

Open Date: 2023-01-01

Close Date: 2026-12-01

Grant: Close

Assessing the bias profile of xanomeline at M1-M5 mAChRs

Open Date: 2022-09-01

Close Date: 2023-08-01

Grant: Close

Understanding xanomeline’s molecular pharmacology to assist in the development of novel neurocognitive therapies

Open Date: 2021-04-01

Close Date: 2022-03-01

Grant: Close

Novel approaches to discovering allosteric probes of muscarinic acetylcholine receptors

Open Date: 2019-01-01

Close Date: 2021-12-01

Articles18

The Prosperity and Adversity of M4 Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders

Article Link

Year:

2025

Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice

Article Link

Year:

2024

Positive allosteric modulation of a GPCR ternary complex

Article Link

Year:

2024

Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

Article Link

Year:

2024

Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges

Article Link

Year:

2024

Role of Conserved Tyrosine Lid Residues in the Activation of the M2Muscarinic Acetylcholine Receptor

Article Link

Year:

2023

Structural basis of efficacy-driven ligand selectivity at GPCRs

Article Link

Year:

2023

Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders

Article Link

Year:

2023

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Article Link

Year:

2023

Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor

Article Link

Year:

2023

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

Article Link

Year:

2023

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Article Link

Year:

2023

Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o- and β-arrestin2-mediated pathways.

Article Link

Year:

2023

Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits

Article Link

Year:

2022

The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor

Article Link

Year:

2022

Structure-activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4.

Article Link

Year:

2022

Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor

Article Link

Year:

2022

Structural Features of Iperoxo–BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy

Article Link

Year:

2022

Collaborators25

Ross Vlahos

Professor

RMIT University Bundoora Campus

AUSTRALIA

David Chalmers

MONASH UNIVERSITY

AUSTRALIA

Alistair Mathie

University of Westminster

UNITED KINGDOM

Emma van der Westhuizen

MONASH UNIVERSITY

AUSTRALIA

Hans Bräuner-Osborne

Københavns Universitet

DENMARK

Ayame Saito

Teaching Associate

MONASH UNIVERSITY

AUSTRALIA

Manuela Joerg

Senior Lecturer

Monash University Malaysia.

AUSTRALIA

Jyrki Kukkonen

University of Helsinki

FINLAND

Xavier Norel

INSERM U1148

FRANCE

David M. Thal

AUSTRALIA

Ahmed Haider

Emory University School of Medicine

UNITED STATES

Davide Malfacini

Assistant professor

University of Padua

ITALY

Alexander Agoulnik

Florida International University

UNITED STATES

antonia cianciulli

University of Bari

ITALY

Arthur Christopoulos

MONASH UNIVERSITY

AUSTRALIA

Klemens Kaupmann

Lab head

SWITZERLAND

Christopher J. Langmead

MONASH UNIVERSITY

AUSTRALIA

Daniel Poole

Associate Professor and Laboratory Head

Monash University Malaysia.

AUSTRALIA

Anthony Peter Davenport

Professor of Cardiovascular Pharmacology

University of Cambridge

UNITED KINGDOM

Patrick M. Sexton

MONASH UNIVERSITY

AUSTRALIA

Eric Prossnitz

Distinguished Professor

University of New Mexico

UNITED STATES

Peter J. Scammells

MONASH UNIVERSITY

AUSTRALIA

Bernhard Bettler

Prof

University of Basel

SWITZERLAND

Philippe Rondard

University of Montpellier

FRANCE

K.H. Christopher Choy

MONASH UNIVERSITY

AUSTRALIA

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Celine Valant

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Recent Grants

Articles18

The Prosperity and Adversity of M<sub>4</sub> Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders

Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice

Positive allosteric modulation of a GPCR ternary complex

Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges

Role of Conserved Tyrosine Lid Residues in the Activation of the M2Muscarinic Acetylcholine Receptor

Structural basis of efficacy-driven ligand selectivity at GPCRs

Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Ligand-directed biased agonism at human histamine H<sub>3</sub> receptor isoforms across Gα<sub>i/o</sub>- and β-arrestin2-mediated pathways.

Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits

The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor

Structure-activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M<sub>4</sub>.

Biased Profile of Xanomeline at the Recombinant Human M<sub>4</sub> Muscarinic Acetylcholine Receptor

Structural Features of Iperoxo–BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy

Collaborators25

Ross Vlahos

David Chalmers

Alistair Mathie

Emma van der Westhuizen

Hans Bräuner-Osborne

Ayame Saito

Manuela Joerg

Jyrki Kukkonen

Xavier Norel

David M. Thal

Ahmed Haider

Davide Malfacini

Alexander Agoulnik

antonia cianciulli

Arthur Christopoulos

Klemens Kaupmann

Christopher J. Langmead

Daniel Poole

Anthony Peter Davenport

Patrick M. Sexton

Eric Prossnitz

Peter J. Scammells

Bernhard Bettler

Philippe Rondard

K.H. Christopher Choy

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