Celine Valant

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MONASH UNIVERSITY

Australia

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Recent Grants

Grant: Open

Modulation of the M4 muscarinic receptor for the treatment of schizophrenia

Open Date: 2023-01-01

Close Date: 2026-12-01

Grant: Open

Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain

Open Date: 2023-01-01

Close Date: 2026-12-01

Grant: Close

Assessing the bias profile of xanomeline at M1-M5 mAChRs

Open Date: 2022-09-01

Close Date: 2023-08-01

Grant: Close

Understanding xanomeline’s molecular pharmacology to assist in the development of novel neurocognitive therapies

Open Date: 2021-04-01

Close Date: 2022-03-01

Grant: Close

Novel approaches to discovering allosteric probes of muscarinic acetylcholine receptors

Open Date: 2019-01-01

Close Date: 2021-12-01

Articles (18)

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2022

Collaborators (25)

Ross Vlahos

Professor

RMIT University Bundoora Campus

AUSTRALIA

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David Chalmers

MONASH UNIVERSITY

AUSTRALIA

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Alistair Mathie

University of Westminster

UNITED KINGDOM

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Emma van der Westhuizen

MONASH UNIVERSITY

AUSTRALIA

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Hans Bräuner-Osborne

Københavns Universitet

DENMARK

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Ayame Saito

Teaching Associate

MONASH UNIVERSITY

AUSTRALIA

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Manuela Joerg

Senior Lecturer

Monash University Malaysia.

AUSTRALIA

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Jyrki Kukkonen

University of Helsinki

FINLAND

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Xavier Norel

INSERM U1148

FRANCE

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David M. Thal

AUSTRALIA

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Ahmed Haider

Emory University School of Medicine

UNITED STATES

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Davide Malfacini

Assistant professor

University of Padua

ITALY

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Alexander Agoulnik

Florida International University

UNITED STATES

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antonia cianciulli

University of Bari

ITALY

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Arthur Christopoulos

MONASH UNIVERSITY

AUSTRALIA

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Klemens Kaupmann

Lab head

SWITZERLAND

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Christopher J. Langmead

MONASH UNIVERSITY

AUSTRALIA

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Daniel Poole

Associate Professor and Laboratory Head

Monash University Malaysia.

AUSTRALIA

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Anthony Peter Davenport

Professor of Cardiovascular Pharmacology

University of Cambridge

UNITED KINGDOM

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Patrick M. Sexton

MONASH UNIVERSITY

AUSTRALIA

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Eric Prossnitz

Distinguished Professor

University of New Mexico

UNITED STATES

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Peter J. Scammells

MONASH UNIVERSITY

AUSTRALIA

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Bernhard Bettler

Prof

University of Basel

SWITZERLAND

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Philippe Rondard

University of Montpellier

FRANCE

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K.H. Christopher Choy

MONASH UNIVERSITY

AUSTRALIA

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Celine Valant

Research Interests

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Contact this professor

Recent Grants

Articles (18)

The Prosperity and Adversity of M<sub>4</sub> Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders

Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice

Positive allosteric modulation of a GPCR ternary complex

Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges

Role of Conserved Tyrosine Lid Residues in the Activation of the M2Muscarinic Acetylcholine Receptor

Structural basis of efficacy-driven ligand selectivity at GPCRs

Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Ligand-directed biased agonism at human histamine H<sub>3</sub> receptor isoforms across Gα<sub>i/o</sub>- and β-arrestin2-mediated pathways.

Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits

The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor

Structure-activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M<sub>4</sub>.

Biased Profile of Xanomeline at the Recombinant Human M<sub>4</sub> Muscarinic Acetylcholine Receptor

Structural Features of Iperoxo–BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy

Collaborators (25)

Ross Vlahos

David Chalmers

Alistair Mathie

Emma van der Westhuizen

Hans Bräuner-Osborne

Ayame Saito

Manuela Joerg

Jyrki Kukkonen

Xavier Norel

David M. Thal

Ahmed Haider

Davide Malfacini

Alexander Agoulnik

antonia cianciulli

Arthur Christopoulos

Klemens Kaupmann

Christopher J. Langmead

Daniel Poole

Anthony Peter Davenport

Patrick M. Sexton

Eric Prossnitz

Peter J. Scammells

Bernhard Bettler

Philippe Rondard

K.H. Christopher Choy

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