Ciro Leonardo Pierri

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Researcher and Professor of Biochemistry and Molecular Modeling

University of Bari Aldo Moro

Italy

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About

Dr. Ciro Leonardo Pierri is a Researcher and Professor of Biochemistry and Molecular Modeling at the University of Bari Aldo Moro in Italy. His research areas encompass immune response modulation through fungal immunomodulatory proteins, three-dimensional modeling of T cell receptor complexes, and metabolic shifts in kidney cancer cells. He also investigates the roles of small compounds on Lonp1 activity and the influence of bioactive molecules in antitumor activities.

Recent Grants

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Inhibitors of the ADP/ATP carriers for triggering mitochondrial apoptosis in cancer cells from kidney, liver and colon

Open Date: 2018-06-01

Close Date: 2020-06-01

Grant: Close

New Mitochondrial delivery systems for the replacement of the impaired OTC, ORC1 and ND5 for the treatment of the related mitochondrial deficiencies

Open Date: 2016-02-01

Close Date: 2018-01-01

Grant: Close

New molecular targets for neuroendocrin cancer treatment

Open Date: 2012-01-01

Close Date: 2015-03-01

Articles (20)

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2021

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2021

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2021

Collaborators (19)

Cosima Damiana Calvano

Associate Professor

University of Bari Aldo Moro

ITALY

Ciro Leonardo Pierri

Research Interests

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About

Recent Grants

Articles (20)

Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length

Sequence/structural/functional relationships between Ganoderma fungal immunomodulatory proteins (gFIPs) and proteins involved in the modulation of immune response

Modulation of Lonp1 Activity by Small Compounds

Exploring Metabolic Shifts in Kidney Cancer and Non-Cancer Cells Under Pro- and Anti-Apoptotic Treatments Using NMR Metabolomics

Carnitine O-Acetyltransferase as a Central Player in Lipid and Branched-Chain Amino Acid Metabolism, Epigenetics, Cell Plasticity, and Organelle Function

Serum Starvation Enhances the Antitumor Activity of Natural Matrices: Insights into Bioactive Molecules from Dromedary Urine Extracts

Supercritical Fluid Extraction of Bioactive Components from Apple Peels and Their Modulation of Complex I Activity in Isolated Mitochondria

Modulatory Effect of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) on the 2-Oxoglutarate Mitochondrial Carrier

Insights into Transient Dimerization of Carnitine/Acylcarnitine Carrier (SLC25A20) from Sarkosyl/PAGE, Cross-Linking Reagents, and Comparative Modelling Analysis

Uncovering a Genetic Diagnosis in a Pediatric Patient by Whole Exome Sequencing: A Modeling Investigation in Wiedemann–Steiner Syndrome

The Mycotoxin Patulin Inhibits the Mitochondrial Carnitine/Acylcarnitine Carrier (SLC25A20) by Interaction with Cys136 Implications for Human Health

The Non-Gastric H+/K+ ATPase (ATP12A) Is Expressed in Mammalian Spermatozoa

Personalized Medicine in Mitochondrial Health and Disease: Molecular Basis of Therapeutic Approaches Based on Nutritional Supplements and Their Analogs

Genome-Wide Identification and Validation of Gene Expression Biomarkers in the Diagnosis of Ovarian Serous Cystadenocarcinoma

Modeling SARS-CoV-2 spike/ACE2 protein-protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally related human protein targets, for COVID-19 handling in the 3PM context.

New Insights Regarding Hemin Inhibition of the Purified Rat Brain 2-Oxoglutarate Carrier and Relationships with Mitochondrial Dysfunction

Citrate Regulates the Saccharomyces cerevisiae Mitochondrial GDP/GTP Carrier (Ggc1p) by Triggering Unidirectional Transport of GTP

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation

The J2-Immortalized Murine Macrophage Cell Line Displays Phenotypical and Metabolic Features of Primary BMDMs in Their M1 and M2 Polarization State

Zoledronic Acid as a Novel Dual Blocker of KIR6.1/2-SUR2 Subunits of ATP-Sensitive K+ Channels: Role in the Adverse Drug Reactions

Collaborators (19)

Cosima Damiana Calvano

antonella aresta

Andrea Gerbino

Cesare Indiveri

Orazio Nicolotti

Anna Vittoria Mattioli

Vittoria Infantino

Salvatrice Ciccarese

Tommaso Cataldi

Annalisa DE PALMA

Mariateresa Volpicella

Maria D'APOLITO

Angelo Vozza

Anna De Grassi

Carlo ZAMBONIN

Giovanni Lentini

Antonio Scilimati

Giuseppe Perrone

Maria Maddalena Cavalluzzi

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