Tassilo Leo Alexander Wachsmann

Leiden University Medical Center

Netherlands

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Articles (13)

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2025

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2025

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2025

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2024

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2024

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2023

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2023

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2022

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2022

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2022

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2021

Collaborators (12)

Peter van Veelen

Leiden University Medical Center

NETHERLANDS

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James McLaren

Senior Lecturer in Immunology

Cardiff University

UNITED KINGDOM

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Marieke Griffioen

Associate Professor

Leiden University Medical Center

NETHERLANDS

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Richard Sessions

University of Bristol

UNITED KINGDOM

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David K Cole

Cardiff University School of Medicine

UNITED KINGDOM

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Jan Wouter Drijfhout

Leiden University Medical Center

NETHERLANDS

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Mirjam H.M. Heemskerk

Associate professor, Head of Laboratory of experimental hematology

Leiden University Medical Center

NETHERLANDS

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Noel de Miranda

Professor

Leiden University Medical Center

NETHERLANDS

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Jeanette Leusen

professor

University Medical Center Groningen

NETHERLANDS

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Linda Wooldridge

University of Bristol

UNITED KINGDOM

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Jurgen Kuball

UMC Utrecht

NETHERLANDS

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Hendrik Veelken

NETHERLANDS

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Tassilo Leo Alexander Wachsmann

Research Interests

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Articles (13)

CAR-mediated target recognition limits TCR-mediated target recognition of TCR- and CAR-dual-receptor-edited T cells

DNA-demethylation by DAC induces MAGE expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets

CRISPR tools for T cells: targeting the genome, epigenome, and transcriptome

Targeting epigenetic regulation and post-translational modification with 5-Aza-2’ deoxycytidine and SUMO E1 inhibition augments T-cell receptor therapy

CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer

Combining BCMA-targeting CAR-T with TCR-engineered T-cell therapy to prevent immune escape of multiple myeloma

High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs

PRAME and CTCFL-reactive TCRs for the treatment of ovarian cancer.

Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain.

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

T cell receptor engineering of primary NK cells to therapeutically target tumors and tumor immune evasion

A library of cancer testis specific T cell receptors for T cell receptor gene therapy.

An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML

Collaborators (12)

Peter van Veelen

James McLaren

Marieke Griffioen

Richard Sessions

David K Cole

Jan Wouter Drijfhout

Mirjam H.M. Heemskerk

Noel de Miranda

Jeanette Leusen

Linda Wooldridge

Jurgen Kuball

Hendrik Veelken

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