Towards non-invasive monitoring and prediction of cancer evolutionary dynamics from cfDNA Institute of Cancer Research in United Kingdom

PhD opportunity at Aston University in the origin of multilocus imprinting disturbance (MLID) , based in Birmingham, United Kingdom . This 3-year full-time project sits in Health & Life Sciences and focuses on DNA methylation , epigenetics , germline variants , epigenetic regulator genes , and the interaction between assisted reproductive technologies (ART) and imprinting disorders. The research aims to characterise detailed methylation profiles and candidate variants in individuals with MLID. S...

Funded PhD opportunity in retrotransposable elements, glioblastoma, cancer biology, immunology, epigenetics, and genomics at The Francis Crick Institute and King's College London . This 2027 Crick–King's College London Joint PhD project is supervised by Dr G Kassiotis (Francis Crick Institute) and Dr Sheila Singh (King's College London). The project investigates how retrotransposable elements (RTEs) , including LINEs, SINEs, and endogenous retroviruses (HERVs) , are reactivated in glioblastoma m...

PhD studentship at the University of Birmingham in the Department of Cancer and Genomic Sciences on molecular drivers of enhancer rewiring in blood cancers , with a focus on multiple myeloma , gene regulation, epigenetics, transcription factors, chromatin activation, and genome organisation. The project investigates how B-lineage transcription factors and chromatin-associated complexes such as Mediator, P300/CBP, and CTCF shape gene regulatory networks in myeloma. The research aims to identify a...

PhD project: The life cycle of ecDNA at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom . This project focuses on ecDNA (extrachromosomal DNA) in cancer, with emphasis on DNA replication , mutagenesis , replication stress , genomics , and molecular biology . The lab is interested in how ecDNA circles replicate, how stalled forks are rescued, and how ecDNA can reintegrate into the host genome to form homogenously staining regions (HSRs). The work also con...

PhD opportunity at The Francis Crick Institute in London, United Kingdom on Determinants of Clonal Fitness in SF3B1-Mutant Clonal Haematopoiesis . This funded PhD project with Dominique Bonnet explores how SF3B1 mutations drive clonal fitness in clonal haematopoiesis , with a strong focus on stem cell biology , RNA splicing , epigenetics , and the ageing bone marrow niche . The project aims to define the molecular mechanisms that give mutant haematopoietic stem cells a competitive advantage, und...