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Volker Lauschke

Has grant

Professor

Karolinska Institutet

Sweden

Research Interests

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Professors in Sweden Professors in Biochemistry Biochemistry professors in Sweden

About

Dr. Volker Lauschke is an Assistant Professor at Karolinska Institutet in Sweden. His research areas encompass pharmacogenomics, diabetes, obesity, and toxicology, as evidenced by his recent publications. His work includes exploring GRK-biased adrenergic agonists for treating metabolic disorders, as well as investigating the effects of phthalates on reproductive toxicity. Additionally, he contributes to the understanding of cellular processes related to human skeletal muscle and cancer through innovative in vitro analyses.

Recent Grants

Grant: Close

Behandling av leversjukdom genom reparation och regeneration av humana hepatocyter in vitro

Open Date: 2017-01-01

Close Date: 2020-01-01

Grant: Close

Användande av ett nytt 3D humant leversystem för prediktion och förståelse av leversjukdomar och läkemedelsinducerad levertoxicitet i frisk och sjuk lever

Open Date: 2017-01-01

Close Date: 2019-01-01

Positions (1)

Amir Ata Saei

University Name

Karolinska Institutet

1 month ago

PhD Position in Proteomics and Insulin Resistance in Metabolic Disease

Karolinska Institutet in Stockholm, Sweden is recruiting a PhD student for a project on proteomics and insulin resistance in metabolic disease . The doctoral project will investigate the molecular mechanisms underlying adipocyte insulin resistance and its reversal after bariatric surgery. The research combines mass spectrometry-based proteomics , deep plasma proteomics , metabolomics , multi-omics integration , bioinformatics , quantitative data analysis, and functional studies in human 3D adipocyte models. The work will be carried out in a collaborative environment with Prof. Mikael Rydén, Prof. Yihai Cao, Prof. Volker Lauschke, and their teams. Applicants should have a strong background in biomedicine, molecular biology, biochemistry, biotechnology, metabolism, bioinformatics, or a related field. Experience in proteomics/metabolomics, quantitative data analysis, or metabolic research is especially valued. This is a PhD opening, not a scholarship announcement. The application deadline is 9 October 2026 . Interested candidates should apply via the linked online portal.

1 month ago

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Collaborators (44)

Erik Eliasson

Professor/Senior Physician

Karolinska Institutet

SWEDEN

Volker Lauschke

Research Interests

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About

Recent Grants

Positions (1)

PhD Position in Proteomics and Insulin Resistance in Metabolic Disease

Articles (49)

Inhibition of the type I interferon receptor pathway protects against muscle weakness induced by dermatomyositis serum

Recombinant spider silk membranes promote human renal epithelial differentiation and function

Association between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure: a retrospective study on two cohorts from Norway and the UK.

A human single-cell atlas identifies OLR1+ scar-associated macrophages as a potential therapeutic target for chronic liver disease.

GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways.

Ferroptosis blockade: beyond preservation to active graft therapy

A translational systems medicine approach to devising nanotherapeutics for targeted intervention of MASLD

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting

Erratum to 'Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk' [Journal of Lipid Research 59/10 (2018) 1987-2000].

Mechanistically resolved prediction of compound hepatotoxicity using primary human liver spheroids-Application to recent real-world cases.

PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature

Prediction of drug hypersensitivity by comprehensive modeling of HLA-peptidomes

A Machine Vision-Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios.

In‐Mold Wettability Patterning of Microfluidic Devices Without Back‐End Surface Modification

Structure-based screening and a conformational biosensor identify a GPR183 inverse agonist and an activation switch

Metabolic assessment of iPSC-derived neurons under ketone-enriched condition: Ketone sensor development and BHB-driven metabolic adaptation.

A thioacrylamide-based compound directly counteracts hepatic fibrosis with profound anti-obesity action

Feed‐Forward Deep Neural Networks Predict Substrate‐Specific Effects of Transporter Variants to Explain Drug Response Variability

Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors.

Comprehensive overview of the global pharmacogenetic and functional variability in NUDT15.

Inactivity-induced NR4A3 downregulation in human skeletal muscle affects glucose metabolism and translation

GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity.

GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity.

A Systematic Literature Review of Reproductive Toxicological Studies on Phthalates

3D Culture in Functionalized FN-Silk Networks Facilitate Proliferation, Differentiation and Phenotypic Stability of Mature Human Primary Cells and Stem Cells.

Opportunities and Challenges of Population Pharmacogenomics.

Synthetic inhibition of the SUMO pathway by targeting the SAE1 component via TAK-981 compound impairs growth and chemosensitizes embryonal and alveolar rhabdomyosarcoma cell lines.

Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP-Lyase Function.

Chemical Switching: A Concept Inspired by Strategies from Biocatalysis and Organocatalysis.

Altered desensitization and internalization patterns of rodent versus human glucose‐dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Deep learning large-scale drug discovery and repurposing

The involvement of the Stat1/Nrf2 pathway in exacerbating Crizotinib-induced liver injury: implications for ferroptosis.

Comparison of drug-induced liver injury risk between propylthiouracil and methimazole: A quantitative systems toxicology approach.

QSPC-06 TIME-SERIES SINGLE-CELL ANALYSES REVEAL INCESSANT REWIRING OF MICROGLIA AFTER OF CRANIAL IRRADIATION

OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids.

Discovery of a novel inhibitor of macropinocytosis with antiviral activity.

Population-scale variability of the human UDP-glycosyltransferase gene family

The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis.

In vitro and ex vivo modeling of enteric bacterial infections

Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction

Structural variation of the coding and non-coding human pharmacogenome

3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation

Two different isoforms of osteopontin modulate myelination and axonal integrity

Calcium measurements in enzymatically dissociated or mechanically microdissected mouse primary skeletal muscle fibers

Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum

Rewiring of catecholamine‐induced calcium signalling is an early event in non‐alcoholic fatty liver disease

A paradigm shift in pharmacogenomics: From candidate polymorphisms to comprehensive sequencing

CFTR reduces the proliferation of lung adenocarcinoma and is a strong predictor of survival in both smokers and non-smokers

Collaborators (44)

Erik Eliasson

Nicholas D. Holliday

Mette Marie Rosenkilde

Joris Hoeks

Stefania Koutsilieri

Dan Larhammar

Gareth Sullivan

Jyrki Kukkonen

Anna Drzazga

Joakim Ek

Juleen Zierath

Helene Alexanderson

Dora Koller

Carina Mallard

Brendan Gabriel

Mikael Sellin

Stefano Gastaldello

Florian Büttner

Anne T. Nies

Peter Lindquist

Kimmie Vestergaard Sørensen

Romain BARRES